For Mechanism:
Injectable Plla Dermal Filler: The mechanism of action occurs through the stimulation of fibroblasts in response to a subclinical tissular inflammation.It is this fibroplasia that produces the desired cosmetic result. New collagen begins to form after one month and continues to increase for nine months to a year. In the sixth month, many PLLA microspheres become porous and surrounded by macrophages. After this period there is no evidence of fibrosis and the PLLA particles disappear. The product`s degradation occurs through non-enzymatic hydrolysis into lactic acid monomers that are metabolized into CO2, H2O or incorporated into glucose. With its half-life estimated at 31 days, PLLA is totally eliminated from the body in about 18 months.
Injectable PMMA Dermal Filler: Polymethylmethacrylate beads (PMMA microspheres): PMMA is a non-biodegradable, biocompatible, man-made polymer. This material is used in other Medical Devices, such as bone cement and intraocular lenses. PMMA beads are tiny, round, smooth particles that are not absorbed by the body. When used as soft tissue filler, PMMA microbeads are suspended in a gel-like solution that contains cow (bovine) collagen and injected into the face. Collagen is a type of protein that is a major part of skin and other tissues in the body. The composition of collagen gel provides immediate volume and lift to correct wrinkles and acne scars. Once collagen is absorbed, PMMA microspheres stay in place and create a base that provides structural support for smoother-looking skin.
Effect Duration:
Injectable PLLA dermal filler: The effect can be seen after injection for 2-3 weeks. However, the duration effect can be as long as 24 months or above.
Injectable PMMA dermal filler: According to Bellafill, the effectiveness and patient satisfaction rates of PMMA dermal filler have been established through 5 years when used to correct nasolabial folds, and 12 months when used to correct acne scars.
Indications:
Injectable PLLA dermal filler: It is suitable for increasing the volume of depressed areas, particularly to correct skin depressions, such as in skin creases, wrinkles, folds, scars and for skin aging. Injectable PLLA is also suitable for large volume corrections of the signs of facial fat loss (lipoatrophy).
Injectable PMMA dermal filler: According to FDA, non-absorbable (permanent) PMMA soft tissue fillers are approved for only nasolabial folds and cheek acne scars.
It is indicated for the correction of nasolabial folds and moderate to severe, atrophic, distensible facial acne scars on the cheek in patients over the age of 21 years. It is also suitable for large volume corrections of the signs of facial fat loss (lipoatrophy).
Edit by Sharon
Rimless Industry Co.,Ltd.