PLLA Mechanism of Action

Once injected, the PLLA microparticles elicit a subclinical foreign body inflammatory response, resulting in encapsulation of the microparticle, followed by fibroplasia and resultant collagen type I deposition in the extracellular matrix .The course of collagen stimulation following injection with PLLA has been explored both in animal models and in human studies and preclinical studies with animal models mirror and support the findings of subsequent human studies.Both preclinical and human studies of tissue response to PLLA illustrate a waning inflammatory response, PLLA degradation, and collagen accumulation over time.Protein adsorption occurs immediately following injection, followed by infiltration by neutrophils and then macrophages .

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